Vancomycin and ototoxicity

Amiodarone. Tetracycline. Fluoroquinolones. Rash (Stevens-Johnson Nephrotoxicity/ototoxicity. Aminoglycosides (neomycin). Vancomycin.

by RK Shields 2024 Cited by 16Serum vancomycin levels do not correlate with ototoxicity, presumably why the authors found no differences in vancomycin trough levels between patients with and

Based on this, the authors recommended therapeutic drug monitoring of vancomycin to reduce the risk of ototoxicity. Ototoxicity secondary to vancomycin is

by C Humphrey 2024 Cited by 24Despite the low risk of vancomycin ototoxicity, it is recommended to discontinue vancomycin in patients experiencing signs of ototoxicity

Secondly, the ototoxicity of vancomycin might be disease-specific, which has been demonstrated for children with pneumococcal meningitis. 25 Thirdly, there are inherent limitations of evaluating ototoxicity in the context of preterm birth due to immaturity of the cochlea. Since the mechanisms by which vancomycin is thought to result in hearing

As of 2024, it appeared that in all cases of permanent SNHL attributed to vancomycin ototoxicity the patient received an aminoglycoside antibiotic just before, during, or shortly after vancomycin. In those cases, vancomycin may have interacted with the aminoglycoside to cause ototoxicity, or that the hearing loss was caused by an aminoglycoside

by U Gomceli 2024 Cited by 16We present a rare case of ototoxicity after oral vancomycin administration and detectable serum vancomycin levels 24 hours after cessation of vancomycin.

of ototoxicity [2, 3], likely inflated due to impurities with older formulations. More recent evaluations found that the risk of ototoxicity from vancomycin ranges 1-9% and is increased with levels 40 mg/L [4]. The true rate from vancomycin monotherapy is low without concurrent use of ototoxic agents.

by LP Rybak 2024 Cited by 35ototoxicity, clarithromycin ototoxicity, macrolide ototoxicity, vancomycin ototoxicity and chloramphenicol ototoxicity. furosemide), but this