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Curiously tylenol metabolized through glucuronidation. Mdma is also metabolized through glucuronidation (eventually). Ibuprofen is not. I m not a doctor, so maybe ask one instead, but i would consider ibuprofen over acetaminophen with mdma.
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The caveat is MDMA and ibuprofen are metabolized by some of the same enzymes, so it may increase your exposure to one or both substances. In terms of needing the ibuprofen, MDMA is a pretty effective analgesic so I doubt you'll feel significant discomfort during the session.
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