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Compare Metformin vs. Phentermine. Head-to-head comparisons of medication uses, side effects, warnings, and more. Metformin. Phentermine (Adipex-P) Metformin.
orlistat, liraglutide, semaglutide, phentermine, topiramate vs metformin and the COCP showed greater reductions in: Body weight
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Phentermine-topiramate was no longer cost-effective when we considered metformin as a comparator. Metformin was less costly and less effective than phentermine-topiramate with an ICER of $64 090/QALY relative to no treatment; however, the additional QALYs gained with phentermine-topiramate vs metformin did not justify its higher costs.
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