Gepant drugs

This novel drug falls under the gepant class of drugs, which also includes other orally administered drugs such as telecagepant, rimegepant, and ubrogepant. Zavegepant is a third-generation gepant, the only intranasally administered drug in the gepant class, which is an advancement from the hepatotoxic initial generations 14 .

The first drugs approved by the Food and Drug Administration (FDA) Gepants. Gepants are taken orally and are small CGRP molecule

drugs target CGRP or the CGRP receptor, monoclonal antibodies and gepants. medications, and gepants are oral CGRP medications. CGRP

CGRP antagonists (gepants) Gepants are the newest class of medications to be developed for acute treatment of migraine symptoms. They do so by

Because the drug families have similar names, CGRP mAbs and CGRP gepants are sometimes confused. Both mAbs and gepants target CGRP. However, these drugs have different purposes. CGRP mAbs prevent migraine. 1,2, . Also, CGRP mAbs are given by injection or IV. CGRP gepants are given by pill or nasal spray. 1,2

Because the drug families have similar names, CGRP mAbs and CGRP gepants are sometimes confused. Both mAbs and gepants target CGRP. However, these drugs have different purposes. CGRP mAbs prevent migraine. 1,2, . Also, CGRP mAbs are given by injection or IV. CGRP gepants are given by pill or nasal spray. 1,2

by Y Aoh 2024History of gepant development. CGRP = calcitonin gene related peptide; FDA = Food and Drug Administration. Table 1 lists the current indications of each gepant.

These drugs, known as gepants, are oral small-molecule CGRP inhibitors. In gepant, telcagepant, was terminated after a data safety monitoring board

(gepant group) against those prescribed triptans but not gepants (triptan group). Medication utilization was also higher in the gepant group for opioids