Bivalirudin half life

by DJ Schneider 2024Because bivalirudin is a substrate for thrombin it has a short half-life of about 25 min. This short half-life could be a double-edged sword, contributing

by H Rivner 2024 Cited by 1argatroban or bivalirudin. PubMed, Cochrane, and manuscript Bivalirudin may serve as a therapeutic alternative in HIT, given its shorter half-life

Half-life: 45 minutes, may be prolonged in hepatic dysfunction. Given as Argatroban, danaparoid, bivalirudin available via EPR link

infusion, plasma bivalirudin concentrations declined biexponentially with an initial half-life of. 27 minutes and a terminal half-life of 77

Bivalirudin's short half-life (25 minutes) may make it easier to stop, compared to a heparin infusion (with half-life close to 45 minutes).

At normothermia, the biologic half-life of bivalirudin is 25 30 minutes, and in our experience the surgical field is usually dry enough to close two half-lives (or approximately 1 hour) after cessation of the bivalirudin infusion.

Indications: Argatroban and bivalirudin can be used in suspected or documented cases of heparin-induced thrombocytopenia. Half-life. minutes. 25 minutes.

Bivalirudin is convenient – ACT monitoring is unnecessary, infusion is only for the duration of the procedure, and half-life is short so that early sheath

Approximately 20% of bivalirudin is cleared from the kidneys and the remainder is proteolyzed. While there are no reversal agents for bivalirudin, it has a much shorter half-life of 25 min in adults and 15 min in newborns, compared to heparin s half-life of 90 min . Therefore, it is not a significant problem using bivalirudin in cases of