Allopurinol half life

MONITOR: Allopurinol may enhance the myelosuppressive side effects of cyclophosphamide. Allopurinol does not appear to increase the serum half-life of

Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.

allopurinol and oxypurinol respectively. Allopurinol has a plasma half-life of 1 to 3 hours. It is converted in the liver primarily to the active metabolite

half-life. As a result, allopurinol can be dosed daily, with lower faces of allopurinol-allopurinol hypersensitivity syndrome. Am J.

Allopurinol may also increase the activity or half-life Co-administration of the following drugs may make allopurinol less active or decrease its half-life:.

Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.

Thai or Korean descent), allopurinol should not be started unless there are no other filtration rate, allopurinol has a plasma half-life of about 1 to

Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.

Chlorpropamide: The half-life of chlorpropamide in the plasma may be prolonged by allopurinol, since allopurinol and chlorpropamide may compete for excretion in