of mental status dose and level of kidney function. Abbreviation: RRT, renal replacem - Baclofen Toxicity in Kidney Disease.
If you have kidney problems or a history of kidney disease, your kidney may not be able to clear baclofen out of your body sufficiently, causing
by O Malle 2024It is contraindicated in chronic kidney disease. As it is eliminated predominantly by the kidneys, acute kidney injury can lead to acute baclofen overdose with
by O Malle 2024It is contraindicated in chronic kidney disease. As it is eliminated predominantly by the kidneys, acute kidney injury can lead to acute baclofen overdose with
Toxicity from therapeutic baclofen in kidney impairment Baclofen accumulates quickly in the body when kidney function is impaired, leading to toxicity.15,16,64 66 There are reports of enceph-alopathy with single doses as little as 5 mg.66 69 The relative risk of encephalopathy in baclofen-treated patients with chronic kidney disease
Baclofen is excreted mostly by the kidneys, with a half-life of ~3 hours. Renal insufficiency may cause baclofen accumulation, with resultant
by O Malle 2024It is contraindicated in chronic kidney disease. As it is eliminated predominantly by the kidneys, acute kidney injury can lead to acute baclofen overdose with
Teaching rounds today: Baclofen toxicity in kidney disease
Patients with chronic kidney disease can develop toxicity within three days of starting baclofen [26]. ○Intrathecal baclofen administration –
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