Acyclovir is an antiviral medication that inhibits DNA polymerase of EBV. Acyclovir s effects on IM have been studied in double-blind, placebo-controlled trials and have demonstrated a suppression in the shedding of EBV in the saliva of infected patients, but EBV replication resumed after treatment was discontinued. 12,13 The use of acyclovir
Acyclovir or Valacyclovir are nucleoside analogues that inhibits permissive EBV infection through inhibition of EBV DNA polymerase. Antiviral treatment.
by JC Luxton 2024 Cited by 22to receive acyclovir, EBV was not isolated from multi- ple throat washing dose oral acyclovir suppresses EBV replication in the oropharynx of most
Acyclovir has no effect on infectious mononucleosis, with its value in EBV encephalitis remaining unclear.( ) EBV encephalitis is
No effective antiviral therapy is available for Epstein-Barr virus (EBV) infectious mononucleosis in immunocompetent persons. Acyclovir and ganciclovir may reduce EBV shedding, but are ineffective clinically. Treatment of immunocompromised patients with EBV lymphoproliferative disease is controversial. Acyclovir has not been proven to be
Acyclovir suppresses EBV lytic reactivation by inhibiting EBV lytic DNA replication, as shown in a study by Drosu et al.
The role of antiviral therapies in the treatment of acute and chronic EBV-associated disease is unclear. Acyclovir reduces EBV replication by inhibiting viral DNA polymerase, and studies have found that both acyclovir and the prodrug valacyclovir reduce oral shedding of EBV in patients with infectious mononucleosis.
As acyclovir and ganciclovir inhibit EBV in vitro [11,34,35], these drugs and their oral prodrugs were evaluated for suppression of EBV reactivation during immunosuppression. PTLD incidence in lung and heart-lung transplant EBV-seronegative recipients was reduced by antiviral prophylaxis with acyclovir, valacyclovir or ganciclovir . The
Acyclovir/ganciclovir: no role in IM. Reduces EBV shedding in the mouth, but no clinical benefit. Ganciclovir employed by some for EBV CNS
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