Acyclovir renal side effects

In addition to neurotoxicity, acute kidney injury is a well-described side effect of acyclovir administration, since crystal deposition may lead to the development of renal failure (4,5). The side-effects of acyclovir therapy are not well recognized by clinicians.

In general, acyclovir is a well-tolerated medication. The adverse effects most often associated with acyclovir are renal dysfunction, related to crystalluria, phlebitis, and neutropenia. Adequate hydration is recommended during acyclovir therapy in order to prevent renal toxicity.

The risk of deposition of acyclovir crystals in the kidney can be avoided by slow drug infusion over 1 to 2 h and volume repletion. Acyclovir-induced renal injury without acyclovir crystal obstruction is also described [21,22]. Another important side effect of acyclovir is neurological toxicity, mainly in patients with renal failure.

acyclovir can induce various side effects ranging from gastrointestinal discomfort and headaches to rare but severe complications such as renal

by MJ Desrumaux 2024Other renal side effects of acyclovir are acute tubular toxicity and interstitial nephritis. Additionally, acyclovir can induce encephalopathy.

by MJ Desrumaux 2024Other renal side effects of acyclovir are acute tubular toxicity and interstitial nephritis. Additionally, acyclovir can induce encephalopathy.

Acyclovir use could lead to renal impairment and an increase in its plasma and CNS concentrations with severe neuropsychiatric side effects. The neurotoxic side

with renal impairment are at increased risk of developing neurological side effects and used, even when this would give an acyclovir

In general, acyclovir is a well-tolerated medication. The adverse effects most often associated with acyclovir are renal dysfunction, related to crystalluria, phlebitis, and neutropenia. Adequate hydration is recommended during acyclovir therapy in order to prevent renal toxicity.