Some chemotherapeutic agents are associated with excessive bone loss. High-dose methotrexate can directly cause bone loss [Schwartz and Leonidas, 2024]; whereas ifosfamide leads to bone loss secondary to renal tubular phosphate wasting [Pfeilschifter and Diel, 2024]. Other drugs, like cyclophosphamide, indirectly induce bone loss due to
2.1 Drugs that slow bone loss Drugs that slow bone loss include Bisphosphonates, selective estrogen receptor modulators, hormone replacement therapy (HRT)
Bisphosphonate drugs are a class of medications that help prevent bone loss in osteoporosis and other conditions that can weaken the skeleton. Bisphosphonate drugs work to slow bone loss . They target osteoclast cells that break down old bone and slow their activity, reducing bone breakdown.
2.1 Drugs that slow bone loss Drugs that slow bone loss include Bisphosphonates, selective estrogen receptor modulators, hormone replacement therapy (HRT)
Bisphosphonates are a class of drugs that prevent bone loss and are used to treat bone metastases, osteoporosis, and Paget's disease.
Reclast is a drug that can treat and prevent osteoporosis by reducing bone loss and promoting bone formation.
bone loss, with distinct advantages over existing drugs bone growth and prevent bone loss. Cell Reports Medicine, 2024; 5 (5):
These drugs reduce the activity of osteoclasts (stop the destruction of bone) to reduce bone loss. This results in a net increase in bone density. Specific
Many drugs can affect bone metabolism. As examples, heparin, warfarin, cyclosporine, glucocorticoids, medroxyprogesterone acetate, cancer drugs, and thyroid hormone can cause bone loss, whereas thiazide diuretics can minimize bone loss [ 1,2 ].
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