Metabolism of amitriptyline

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Actual: DG Amitriptyline D Amitriptyline DG Tricyclic antidepressant. DG Amitriptyline D Amitriptyline Metabolizing enzyme substrate. DG
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Amitriptyline is metabolized to an active metabolite (nortriptyline) so the effects of amitriptyline are long-lasting. The antidepressant effect

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Amitriptyline should be used with caution in patients Biotransformation. In vitro the metabolism of amitriptyline proceeds mainly by demethylation.

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Metabolism: Amitriptyline is metabolized to nortriptyline by CYP2C19. CYP3A4 and CYP2D6 are also involved in the metabolism of amitriptyline. Excretion: Amitriptyline has a half-life of 10 to 28 hours. Amitriptyline and its metabolites are primarily excreted by the kidney.

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by A Thour 2024 Cited by 44Metabolism: Amitriptyline is metabolized to nortriptyline by CYP2C19. CYP3A4 and CYP2D6 are also involved in the metabolism of amitriptyline.[10][11].

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Nortriptyline and amitriptyline are very similar. In fact, amitriptyline metabolizes into nortriptyline after taking it.

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DG Amitriptyline D Amitriptyline DG Tricyclic antidepressant. DG Amitriptyline D Amitriptyline Metabolizing enzyme substrate. DG

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Amitriptyline, The metabolism of Amitriptyline can be decreased when combined with Vonoprazan. Amprenavir, The metabolism of Vonoprazan can be decreased

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Metabolism: Amitriptyline is metabolized to nortriptyline by CYP2C19. CYP3A4 and CYP2D6 are also involved in the metabolism of amitriptyline. Excretion: Amitriptyline has a half-life of 10 to 28 hours. Amitriptyline and its metabolites are primarily excreted by the kidney.

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metabolism. Use Caution/Monitor. amitriptyline. fluconazole will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism.

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