PGF2 alpha has the capacity to release oxytocin from the corpus luteum, and oxytocin in turn releases PGF2 alpha from the uterine endometrium or decidua. This positive feedback loop between the ovary and the uterus ensures the completion of luteolysis in species that depend on the presence of the uterus for the termination of luteal lifespan
Alteration in oxytocin levels induced by early social environment affects maternal behavior and estrogen receptor alpha in mandarin Natural variation in paternal behavior is associated with central estrogen receptor alpha and oxytocin levels, Journal of comparative physiology. A Neuroethol. Sens. Neural Behav. Physiol, 201 (3) (2025), pp
The control group received a standard intravenous oxytocin regimen. The PGF2 alpha treated group had a significantly shorter length of labour (6.2 /- 3.6 hours) compared to the oxytocin group (7.5 /- 4.3 hours) (p less than 0.05). The analgesic requirements were significantly reduced in the PGF2 alpha treated patients.
Some of these effects are likely caused by open ring/linear C-terminal fragments activating alpha 2-adrenoreceptors. Oxytocin fragments may be pre-formed and released in the brain or created by metabolic conversion of the principal hormone oxytocin in the central nervous system. Oxytocin and its fragments may also be released from peripheral
After PGF2 alpha injection, 200 IU of oxytocin was given IM and motility was recorded for 2 to 4 hours. Twenty-four hours later, oxytocin treatment was administered, and 2 to 4 hours later, PGF2 alpha was given. The tension-time index was calculated. When PGF2 alpha was given initially, it did not affect (P greater than 0.05) uterine motility.
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Tad-Oxy-PT141 is a combination of tadalafil, oxytocin and PT-141, a drug that enhances sexual desire and function. It is taken daily and works for both males and females with erectile
In addition to classical OTR mediated actions, the anti-stress effects of oxytocin also involve alpha 2 adrenoceptors, which inhibit noradrenergic function. Oxytocinergic activation of alpha 2 adrenoceptors is particularly prominent after long term exposure to oxytocin and is associated with long lasting effects. When oxytocin is administered
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