Celecoxib for dogs

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Actual: celecoxib ; Celaxib (New Formulation), PICMI, Celecoxib ; Celebrex, PICMI, Celecoxib ; Celecoxib APOTEX, PICMI, celecoxib ; Celecoxib GH, CMIPI, celecoxib.
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The pharmacokinetics of celecoxib, a cyclooxygenase-2 inhibitor, was characterized in beagle dogs. Celecoxib is extensively metabolized by dogs to a hydroxymethyl metabolite with subsequent oxidization to the carboxylic acid analog. There are at least two populations of dogs, distinguished by their

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Meloxicam (Metacam) is available for use in dogs Hepatic microsomes from EM dogs metabolized celecoxib at a higher rate than microsomes from PM dogs.

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by SK Paulson 2024 Cited by 31In dog, celecoxib is metabolized in vitro to the hydroxymethyl metabolite with were EM of celecoxib; dogs with a 24-h plasma celecoxib concentration above the

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This terminology was based on an in vitro study in which CYP2D15 was purported to metabolise celecoxib. Dogs with the PM phenotype showed a

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Meloxicam (Metacam) is available for use in dogs in Canada and now approved Celecoxib (Celebrex) is a new nonsteroidal anti-inflammatory drug. In

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The mean ( S.D.) plasma elimination half-life and clearance of celecoxib were 1.72 0.79 h and 18.2 6.4 ml/min/kg for EM dogs and 5.18 1.29 h and 7.15 1.41 ml/min/kg for PM dogs. Hepatic microsomes from EM dogs metabolized celecoxib at a higher rate than microsomes from PM dogs.

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