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The pharmacokinetics of celecoxib, a cyclooxygenase-2 inhibitor, was characterized in beagle dogs. Celecoxib is extensively metabolized by dogs to a hydroxymethyl metabolite with subsequent oxidization to the carboxylic acid analog. There are at least two populations of dogs, distinguished by their
Meloxicam (Metacam) is available for use in dogs Hepatic microsomes from EM dogs metabolized celecoxib at a higher rate than microsomes from PM dogs.
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by SK Paulson 2024 Cited by 31In dog, celecoxib is metabolized in vitro to the hydroxymethyl metabolite with were EM of celecoxib; dogs with a 24-h plasma celecoxib concentration above the
This terminology was based on an in vitro study in which CYP2D15 was purported to metabolise celecoxib. Dogs with the PM phenotype showed a
Meloxicam (Metacam) is available for use in dogs in Canada and now approved Celecoxib (Celebrex) is a new nonsteroidal anti-inflammatory drug. In
The mean ( S.D.) plasma elimination half-life and clearance of celecoxib were 1.72 0.79 h and 18.2 6.4 ml/min/kg for EM dogs and 5.18 1.29 h and 7.15 1.41 ml/min/kg for PM dogs. Hepatic microsomes from EM dogs metabolized celecoxib at a higher rate than microsomes from PM dogs.
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Aside from upsetting me with potentially making dogs extremely sick though, I liked your story :)