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Author: Admin | 2025-04-28
Range (t1–t2) [37]. DE was calculated by using the following Eq (8).(8)Where;y = is the percentage dissolved at time t. The integral of the numerator which is the area under the curve was calculated using the following Eq (9).(9)Where;ti = is the ith time point, and yi is the % of dissolved product at time t.Mean dissolution time. Mean dissolution time was also considered in the study to characterize the drug release rate from the dosage form and the retarding efficiency of the polymer [38], and calculated using Eq (10).(10)Where;ti, = is an intermediate time of the intervals of sampling timeΔQi = is the amount of API dissolved in every interval of t”,Q∞ is the maximum of API dissolved.Model dependent approaches.A Several mathematical models have been proposed to study dissolution profiles in order to decide the kinetics of drug release [39]. The models were evaluated by selecting a certain parameters based on % cumulative drug releases vs. time taken. To understand azithromycin drug release kinetics, various mathematical models dependent approaches were employed (Table 3).ResultsSix different brands of Azithromycin tablets with a label strength of 500 mg were obtained from a private and hospital pharmacy in Adama and Modjo town, five of which were manufactured in three different countries (India, Turkey, and Greece), and one from a local manufacturer. When the study was conducted, all of the products were within their expiration dates.The result of tested Azithromycin tabletsThe different brands of Azithromycin tablets under study were evaluated for various physical parameters
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