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Author: Admin | 2025-04-28
Prescribing naloxone, based on the patient’s risk factors for overdose, such as concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose. The presence of risk factors for overdose should not prevent the proper management of pain in any given patient [see WARNINGS; Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression; Life-Threatening Respiratory Depression; Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants]. Consider prescribing naloxone when there are household members (including children) or other close contacts at risk for accidental ingestion or overdose. Initial Dosage Initiating Treatment with Hydrocodone Bitartrate and Aspirin Tablets Initiate treatment with Hydrocodone Bitartrate and Aspirin Tablets using one (1) or two (2) tablets every four (4) to six (6) hours, as needed for pain at the lowest dose necessary to achieve adequate analgesia. Titrate the dose based upon the individual patient’s response to their initial dose of Hydrocodone Bitartrate and Aspirin Tablets. Conversion from Other Opioids to Hydrocodone Bitartrate and Aspirin Tablets There is inter-patient variability in the potency of opioid drugs and opioid formulations. Therefore, a conservative approach is advised when determining the total daily dosage of Hydrocodone Bitartrate and Aspirin Tablets. It is safer to underestimate a patient’s 24-hour Hydrocodone Bitartrate and Aspirin Tablets dosage than to overestimate the 24-hour Hydrocodone Bitartrate and Aspirin Tablets dosage and manage an adverse reaction due to an overdose. Conversion from Hydrocodone Bitartrate and Aspirin Tablets to Extended-Release Hydrocodone The relative bioavailability of Hydrocodone Bitartrate and Aspirin Tablets compared to extended-release hydrocodone is unknown, so conversion to extended-release hydrocodone may lead to increased risk of excessive sedation and respiratory depression. Titration and Maintenance of Therapy Individually titrate Hydrocodone Bitartrate and Aspirin Tablets to a dose that provides adequate analgesia and minimizes adverse reactions. Continually reevaluate patients receiving Hydrocodone Bitartrate and Aspirin Tablets to assess the maintenance of pain control, signs and symptoms of opioid withdrawal, and other adverse reactions, as well as reassess for the development of addiction, abuse, or misuse [see WARNINGS]. Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family
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