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Author: Admin | 2025-04-28
Apr 24, 2019 HLT asked I currently have a prescription for 25 mg HCTZ and 10 mg lisinopril to treat high blood pressure. When I take them together in the morning, my blood pressure goes too low (90/68) ….. if I take the HCTZ in the morning and the lisinopril at night it seems to maintain a healthy blood pressure. Is there a problem doing that? Answer You can take HCTZ (hydrochlorothiazide) and lisinopril at any time during the day, but there are some recommendations to get the most benefit from them and reduce side effects.The first thing you should do is discuss the issue with your doctor regarding your blood pressure dropping too low. This could be indicative that the dose of one or both may need adjusting.However, if your blood pressure is well-controlled (and doesn't drop too low) when taking the HCTZ in the morning, and lisinopril at night, that is perfectly fine in most cases.In fact, this may be the ideal way to take both medications.HCTZ In The MorningHCTZ (hydrochlorothiazide), a thiazide diuretic, can be taken anytime during the day but morning dosing is typically recommended.[1]Since HCTZ is a diuretic, and causes fluid loss through urination, taking it in the evening can cause interruptions with sleep since you may need to go to the bathroom more often.[2]Therefore, taking it in the morning may be wise to avoid disrupting your sleep.Having said all of this, there have been some studies that suggest taking diuretics at nighttime lower blood pressure more effectively than taking them earlier in the day.[3]While this certainly may conflict with the negative effects of having to use the bathroom in the middle of the night, most studies point out the diuretic (i.e. water loss) effect of thiazide diuretics only lasts a few weeks after starting
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