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Author: Admin | 2025-04-28
Minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing.If irritation or other adverse reaction occurs (for example, increased heart rate, tremor, muscle cramps), seek medical attention.In case of accidental oral exposure or injection, seek medical attention. Caution should be used while handling and using filled syringes.Users with cardiovascular disease (for example, hypertension or ischemic heart disease) should take special precautions to avoid any exposure to this product.The safety data sheet (SDS) contains more detailed occupational safety information.To report adverse reactions in users or to obtain a copy of the SDS for this product call 1-800-887-2763.Note to Physician: This product contains an alpha2-adrenergic antagonist.PRECAUTIONS1. Handling: Atipamezole hydrochloride can produce an abrupt reversal of sedation; therefore, dogs that have recently received atipamezole hydrochloride should be handled with caution. The potential for apprehensive or aggressive behavior should be considered in the handling of dogs emerging from sedation, especially in dogs predisposed to nervousness or fright. Also, avoid situations where a dog might fall.2. Sedation relapse: While atipamezole does reverse the clinical signs associated with medetomidine or dexmedetomidine sedation, complete physiologic return to pretreatment status may not be immediate or may be temporary, and dogs should be monitored for sedation relapse. Sedation relapse is more likely to occur in dogs that receive an alpha2-agonist by the IV route, compared to dogs that are sedated using the IM route. Animals should be monitored closely for persistent hypothermia, bradycardia, and depressed respiration, until signs of recovery persist.3. Analgesia reversal: Atipamezole reverses analgesic effects as well as sedative effects. Additional procedures for the control of pain may be required.4. Debilitated dogs: The safety of atipamezole has not been evaluated in dogs with compromised health. Geriatric, debilitated, and ill dogs are more likely to experience adverse reactions associated with the administration of alpha2-antagonists (as well as alpha2-agonists). Dogs with abnormalities associated with the cardiovascular system are especially at risk.5. Breeding dogs: Atipamezole hydrochloride has not been evaluated in breeding dogs; therefore, the drug is not recommended for use in pregnant or lactating dogs, or in dogs intended for breeding.6. Minimum age and
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