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Author: Admin | 2025-04-28
Be careful when taking ibuprofen with blood pressure medicines because the combination may cause serious kidney damage in some people, particularly older adults or people who are dehydrated. The risk is higher if you also take a diuretic (water pill), in addition to your blood pressure medications. People taking blood pressure medications AND diuretics should avoid taking ibuprofen.If you take blood pressure medications, then you should always talk to your healthcare provider before taking ibuprofen. Do not just buy it from a supermarket or drug store without telling your healthcare provider you are taking it. This is so that they can monitor the effects it has on your kidneys. Ibuprofen can also counteract the effects of blood pressure medications, so your healthcare provider will need to check your blood pressure regularly as well.The interaction between blood pressure medications and ibuprofen happens because your kidneys rely on prostaglandins for blood flow and ibuprofen reduces prostaglandin levels in the body. In some people this can seriously affect blood flow through the kidneys and cause an acute kidney injury, with symptoms such as passing less urine or more dilute urine than usual, feeling sick or vomiting, leg swelling, or pain in your abdomen or the middle of your back. In general, the combination of ibuprofen and blood pressure medications is not recommended, but if there is a good reason to use it, ibuprofen should be used at the lowest recommended dosage for a few days only under medical supervision (not self-prescribed)Blood pressure medications, such as ACE inhibitors or ARBs; diuretics; and NSAIDs all decrease kidney function. Prescribing two of these drugs together increases the risk (called the double whammy) but the risk is greatest when all three are prescribed at once (called the triple whammy).Ibuprofen, and other NSAIDs, can also decrease the blood pressure-lowering effects of other blood pressure medications, such as alpha-blockers, calcium antagonists, and beta blockers meaning that your blood pressure could increase. NSAIDs can also reduce the effects of diuretics, which can exacerbate heart failure. This may put you at increased risk of a heart attack or stroke. Adjusting medication dosages (such as increasing the dose of the blood pressure medication because ibuprofen is making it less effective), is not good prescribing practice and is likely to increase the risk of side effects, including kidney damage. If ibuprofen is making your blood pressure medication less effective, then you should stop taking ibuprofen.List of blood pressure medications that can interact with ibuprofenACE inhibitors or ARBsExamples of ACE inhibitors or ARBs that can interact with ibuprofen include:candesartancaptoprilenalaprilirbesartanlosartanlisinoprilquinaprilperindoprilvalsartan.DiureticsExamples of diuretics that can interact with ibuprofen include:bendroflumethiazidebumetanidechlorthalidoneeplerenonefurosemidehydrochlorothiazide (HCTZ)indapamidemetolazonespironolactone.Combination ACE inhibitors/ARBs with diureticscandesartan/hydrochlorothiazideenalapril/hydrochlorothiazideirbesartan/hydrochlorothiazidelosartan/hydrochlorothiazidelisinopril/hydrochlorothiazidevalsartan/hydrochlorothiazidevalsartan/hydrochlorothiazide/amlodipine.List of NSAIDs that can interact with blood pressure medicationsIbuprofen is not the only NSAID that can interact with blood pressure medications and diuretics. Examples of other NSAIDs include:celecoxibcelecoxib combinations (eg, celecoxib/tramadol)diclofenacibuprofenibuprofen/acetaminophen combinationnaproxenpiroxicammeloxicamsulindacaspirinaspirin combinations (eg, aspirin/butalbital/caffeine).Related questionsCan you take Ibuprofen if you have COVID-19 (coronavirus)?Naproxen vs ibuprofen: What's the difference?Can you take ibuprofen on an empty stomach?Why does ibuprofen interact with blood pressure
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