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Author: Admin | 2025-04-28
Published: Feb 12, 2018 Last Updated: Oct 26, 2019 In our latest question and answer, the pharmacist discusses whether or not oxycodone can safely be taken with Zoloft (sertraline). Feb 11, 2018 tjm5711 asked Can Zoloft (sertraline) be taken with oxycodone safely? Answer There is a moderate interaction between oxycodone and Zoloft (sertraline hydrochloride) and caution is advised when used together. The combined use of the oxycodone and Zoloft increases the risk of additive serotonin-related side effects and serotonin syndrome. Taking Zoloft With OxycodoneZoloft (sertraline) is classified as a SSRI (selective serotonin re-uptake inhibitor). SSRI drugs are used for a variety of indications including depression, anxiety and bipolar disorder. They work by increasing the neurotransmitter serotonin in the brain.Oxycodone is an opioid analgesic. While opioids don't directly affect serotonin, recent evidence suggests that there are certain "serotonergic opioids" which can indirectly increase serotonin levels via multiple mechanisms.Serotonin syndrome is a rare, but serious condition that can occur when high levels of serotonin build up in the brain, causing toxicity. Symptoms of serotonin syndrome include:AgitationVisual disturbancesElevated heart rateFeverSweatingSpamsShiveringStiffnessWhile the incidence rate of serotonin syndrome in those taking SSRI antidepressants and opioids appears to be low, the risk is nonetheless there. Several studies have been published that detail serotonin syndrome cases in individuals using the combination.In fact, the FDA released a safety announcement regarding the risk of combining antidepressants that affect serotonin and opioid medications.While the potential interaction between Zoloft and oxycodone doesn't contraindicate their use together, it is important to be aware of the risks and potential symptoms of serotonin syndrome. In addition, it would be prudent to avoid combining additional medications that could potentially increase serotonin levels. Dr. Brian Staiger Pharm.D Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of the Q+A website PharmacistAnswers.com.
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