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Author: Admin | 2025-04-28
Pseudomembranous enterocolitisRare (0.01% to 0.1%): Fecal incontinence, pelvic peritonitisFrequency not reported: Feces discolored, melenaPostmarketing reports: Teeth staining[Ref]Small intestinal obstruction, C difficile infection or colitis, dry mouth, and hematochezia were reported in a study using 1 g of this drug for prophylaxis of surgical site infection after elective colorectal surgery.[Ref]HepaticCommon (1% to 10%): Increased ALT, increased AST, increased direct serum bilirubin, increased total serum bilirubinUncommon (0.1% to 1%): Increased indirect serum bilirubin, cholelithiasis, jaundice, increased direct and indirect serum bilirubinRare (0.01% to 0.1%): Cholecystitis, liver disorder, increased urobilinogen[Ref]LocalCommon (1% to 10%): Infused vein complication, phlebitis/thrombophlebitisUncommon (0.1% to 1%): Injection site induration, injection site painFrequency not reported: Tenderness, ecchymosis, infusion site pain, infusion site burning, infusion site pruritus, infusion site erythema, injection site erythema, infusion site warmth, infusion site phlebitis, infusion site swelling[Ref]Nervous systemCommon (1% to 10%): Headache, dizzinessUncommon (0.1% to 1%): Cerebrovascular accident, syncope, somnolence, seizure, tremor, hypesthesia, spasm, paresthesia, vertigo, taste perversionPostmarketing reports: Coordination abnormal, depressed level of consciousness, dyskinesia, gait disturbance, myoclonus, tremor[Ref]Cerebrovascular accident was reported in a study using 1 g of this drug for prophylaxis of surgical site infection after elective colorectal surgery.In clinical trials, seizures were reported in 0.5% of patients, most often in patients with central nervous system disorders (e.g., brain lesions, seizure history) and/or renal dysfunction. A case report describes a patient on continuous ambulatory peritoneal dialysis who had multiple tonic-clonic seizures after receiving 2 doses of this drug.[Ref]OtherCommon (1% to 10%): Wound infection, increased serum alkaline phosphatase, fever, edema/swelling, wound complication, death, postoperative
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